A healthy uvea—the middle layer of the eye—is essential for normal vision. Noninfectious uveitis affecting the back segment of the eye is a type of inflammation of the uvea that may lead to impaired vision or loss of vision.

How healthy eyes work
What is noninfectious uveitis
affecting the back segment of
the eye?
Symptoms and effects

How the eye works

Light enters through the cornea, passes through the opening in the iris, called the pupil, and then to the lens, which focuses light on the retina—the inner lining of the back of the eye.

The uvea’s role
The uvea, or uveal tract, is the middle layer of the eye. The 3 parts of the uvea—the iris, ciliary body, and choroid—have important functions:

  • The iris, which is the colored part of the eye, contracts and dilates to control how much light enters the eye. By adjusting, it allows you to see under a variety of lighting conditions
  • The ciliary body releases aqueous humor, which nourishes the front part of the eye. It also contains the ciliary muscle, which changes the shape of the lens to help you focus
  • The choroid is a layer of connective tissue and blood vessels located between the sclera (white of the eye) and the retina. The choroid nourishes the inner parts of the eye

The retina’s role
The retina is lined with light-sensitive cells, or photoreceptors, called rods and cones. The macula is the center of the retina and is responsible for sharp central vision. The fovea is a small depression in the macula that provides the sharpest vision of all.


When light reaches the retina, the photoreceptors send impulses along the optic nerve to the brain, which interprets them as vision.

What is noninfectious uveitis affecting the back segment of the eye?

Uveitis (pronounced you-vee-eye-tis) is inflammation of the uvea. Inflammation is caused by retinal cells, your immune system’s white blood cells, and the chemicals these cells release.

Noninfectious uveitis
Noninfectious uveitis means that although the uvea is inflamed, no bacteria or viruses are found in the eye. The inflammation may be caused indirectly by a disease affecting one of your body’s other systems, but often no cause can be found. When that is the case, patients may be having an autoimmune reaction, which means that, for an unknown reason, the body is reacting to some of its own cells as if they were foreign invaders, creating vitreous haze.

Noninfectious uveitis affecting the back segment of the eye
Back-of-the-eye uveitis may include the middle section of the uvea around the ciliary body (reaching the edge of the retina). It may also affect the choroid and other parts of the back of the eye, including the entire retina and the blood vessels of the retina.

Uveal inflammation affecting the back segment of the eye (highlighted in red)

Symptoms and effects of noninfectious uveitis affecting the back segment of the eye

Symptoms
Noninfectious uveitis affecting the back segment of the eye is usually painless. Your vision may be decreased and you may see irregular floating black spots (floaters).

More severe posterior uveitis affecting the retina can lead to significant loss of vision.

Effects
The inflammation associated with noninfectious uveitis affecting the back segment of the eye can cause immune cells to enter the vitreous gel that fills the back of your eye, creating what is known as vitreous haze. The haze can contribute to decreased vision.

Uveitis can damage the eye and cause long-term complications that reduce vision. While many people have only a single episode of uveitis, others may have recurrences over months to years. It is very important to receive medical treatment for the inflammation of uveitis affecting the back segment of the eye.

OZURDEX® (dexamethasone intravitreal implant) is an FDA-approved treatment for adults with noninfectious uveitis affecting the back segment of the eye.

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RVO - swelling of the macula following branch or central retinal vein occlusion

IMPORTANT SAFETY INFORMATION
When Not to Use OZURDEX® OZURDEX® should not be used if you have any infections in or around the eyes, including most viral diseases of the cornea and conjunctiva, including active herpes viral infection of the eye, vaccinia, varicella, mycobacterial infections, and fungal diseases. See more below

IMPORTANT SAFETY INFORMATION
When Not to Use OZURDEX®
OZURDEX® should not be used if you have any infections in or around the eyes, including most viral diseases of the cornea and conjunctiva, including active herpes viral infection of the eye, vaccinia, varicella, mycobacterial infections, and fungal diseases.

OZURDEX® should not be used if you have glaucoma that has progressed to a cup-to-disc ratio of greater than 0.8.

OZURDEX® should not be used if you have a posterior lens capsule that is torn or ruptured.

OZURDEX® should not be used if you are allergic to any of its ingredients.

Warnings and Precautions
Injections into the vitreous in the eye, including those with OZURDEX®, are associated with serious eye infection (endophthalmitis), eye inflammation, increased eye pressure, and retinal detachments. Your eye doctor should monitor you regularly after the injection.

Use of corticosteroids including OZURDEX® may produce posterior subcapsular cataracts, increased eye pressure, glaucoma, and may increase the establishment of secondary eye infections due to bacteria, fungi, or viruses. Let your doctor know if you have a history of ocular herpes simplex as corticosteroids are not recommended in these patients.
See more below

IMPORTANT SAFETY INFORMATION
When Not to Use OZURDEX® OZURDEX® should not be used if you have any infections in or around the eyes, including most viral diseases of the cornea and conjunctiva, including active herpes viral infection of the eye, vaccinia, varicella, mycobacterial infections, and fungal diseases.

OZURDEX® should not be used if you have glaucoma that has progressed to a cup-to-disc ratio of greater than 0.8.

OZURDEX® should not be used if you have a posterior lens capsule that is torn or ruptured.

OZURDEX® should not be used if you are allergic to any of its ingredients.

Warnings and Precautions
Injections into the vitreous in the eye, including those with OZURDEX®, are associated with serious eye infection (endophthalmitis), eye inflammation, increased eye pressure, and retinal detachments. Your eye doctor should monitor you regularly after the injection.

Use of corticosteroids including OZURDEX® may produce posterior subcapsular cataracts, increased eye pressure, glaucoma, and may increase the establishment of secondary eye infections due to bacteria, fungi, or viruses. Let your doctor know if you have a history of ocular herpes simplex as corticosteroids are not recommended in these patients.

Common Side Effects in Diabetic Macular Edema
The most common side effects reported in patients with diabetic macular edema include: cataract, increased eye pressure, conjunctival blood spot, reduced vision, inflammation of the conjunctiva, specks that float in the field of vision, swelling of the conjunctiva, dry eye, vitreous detachment, vitreous opacities, retinal aneurysm, foreign body sensation, corneal erosion, inflammation of the cornea, anterior chamber inflammation, retinal tear, drooping eyelid, high blood pressure, and bronchitis.

Common Side Effects in Retinal Vein Occlusion and Uveitis
The most common side effects reported in patients for retinal vein occlusion and uveitis include: increased eye pressure, conjunctival blood spot, eye pain, eye redness, ocular hypertension, cataract, vitreous detachment, and headache.
See more below

Approved Uses
OZURDEX® (dexamethasone intravitreal implant) is a prescription medicine that is an implant injected into the eye (vitreous) and used:
  • To treat adults with diabetic macular edema
  • To treat adults with swelling of the macula (macular edema) following branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO)
  • To treat adults with noninfectious inflammation of the uvea (uveitis) affecting the back segment of the eye
IMPORTANT SAFETY INFORMATION (continued)
Common Side Effects in Diabetic Macular Edema

The most common side effects reported in patients with diabetic macular edema include: cataract, increased eye pressure, conjunctival blood spot, reduced vision, inflammation of the conjunctiva, specks that float in the field of vision, swelling of the conjunctiva, dry eye, vitreous detachment, vitreous opacities, retinal aneurysm, foreign body sensation, corneal erosion, inflammation of the cornea, anterior chamber inflammation, retinal tear, drooping eyelid, high blood pressure, and bronchitis.

Common Side Effects in Retinal Vein Occlusion and Uveitis

The most common side effects reported in patients for retinal vein occlusion and uveitis include: increased eye pressure, conjunctival blood spot, eye pain, eye redness, ocular hypertension, cataract, vitreous detachment, and headache.

Patient Counseling Information

After repeated injections with OZURDEX®, a cataract may occur. If this occurs, your vision will decrease and you will need an operation to remove the cataract and restore your vision.You may develop increased eye pressure with OZURDEX® that will need to be managed with eye drops, and rarely, with surgery.

In the days following injection with OZURDEX®, you may be at risk for potential complications including in particular, but not limited to, the development of serious eye infection or increased eye pressure. If your eye becomes red, sensitive to light, painful, or develops a change in vision, you should seek immediate care from your eye doctor. You may experience temporary visual blurring after receiving an injection and should not drive or use machinery until your vision has resolved.

Please click here for full Prescribing Information.